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Epilepsy has afflicted humankind throughout recorded history; yet, it is only in the last half-century, that significant progress has been made in our basic understanding of the epileptic brain. Pivotal advances in drug development and surgical techniques, as well as the emergence of innovative approaches such as electrical stimulation of the nervous system, have led to a substantial reduction in the morbidity and mortality of patients with epilepsy. At the same time, remarkable developments in neuroscience have enhanced our understanding of brain structure and function.Epilepsy: Mechanisms, Models, and Translational Perspectives incorporates new translational advances that bring epilepsy therapies from the laboratory bench to the bedside and back again. It brings together the work of more than 70 of the field’s most respected and cutting-edge researchers and clinicians. In 24 chapters, this extraordinarily comprehensive and current work:Offers an overview of the basic anatomic and functional substrates of seizure genesis and considers novel pathogenic concepts that have both emerged and been validated experimentallyExamines antiepileptic drug therapy, including the latest on molecular targets Looks at the state of surgical treatments for epilepsy and discusses advances in the fields of structural and functional neuroimaging Reviews the variety of nontraditional therapeutic options, such as the ketogenic diet, the vagus nerve stimulator, immunomodulators, neurosteroids, herbs, and botanicals Investigates neuroendocrine, hormonal, and biobehavioral factors that influence seizure susceptibility—information that can be incorporated into the design of treatment algorithms on an individualized basis Provides a glimpse of what future epilepsy therapies might look like, from novel mechanisms of drug delivery to gene and stem-cell therapies for epilepsy to seizure detection methods, to the ultimate goal of disease prevention. The idea for this book was inspired by the editors’ collective desire to promote bridging of the so-called translational divide—that is, covering innovative treatment strategies based on scientific principles that have yet to be tested rigorously in the clinical setting, but yet may provide practitioners with new and promising approaches toward epilepsy therapeutics. Drug treatment of epilepsy in adults The BMJ Epilepsy is a serious potentially life shortening brain disorder the symptoms of which can be successfully treated in most patients with one or more antiepileptic drug. Is the Ketogenic Diet the Cure for Multiple Diseases? Health Impact News Comments: The ketogenic diet was developed at John Hopkins hospital in the 1920s as a natural cure for epilepsy when drugs failed. National Institute of Neurological Disorders and Stroke 2015 Conferences. BRAIN Initiative Workshop: Industry Partnerships to Facilitate Early Access to Modulation and Recording Devices for Human Clinical Studies Videocast ... Research & Training Kennedy Krieger Institute HUGO MOSER RESEARCH INSTITUTE OVERVIEW. Kennedy Kriegers scientists and researchers are leaders in the worldwide effort to prevent and treat disorders of the brain ... B-Cell Depletion with Rituximab in RelapsingRemitting ... Multiple sclerosis the prototypical inflammatory demyelinating disease of the central nervous system is second only to trauma as a cause of acquired neurologic ... Alzheimer's disease - Wikipedia Alzheimer's disease; Synonyms: Alzheimer disease: Comparison of a normal aged brain (left) and the brain of a person with Alzheimer's (right). Characteristics that ... Home : Nature Reviews Neurology Current Issue News & Views Gene therapy: Gene-editing therapy for neurological disease. Moira A. McMahon & Don W. Cleveland. Guide RNA-mediated CRISPRCas nucleases ... Mitochondrial DNA mutations and human disease Fig. 1. Human mitochondrial genome. Represented is a schematic diagram of the 16.6 kb circular double-stranded human mitochondrial genome with an enhanced view of ... Osteopetrosis NEJM Review Article. Mechanisms of Disease. Osteopetrosis. Jakub Tolar M.D. Ph.D. Steven L. Teitelbaum M.D. and Paul J. Orchard M.D. N Engl J Med 2004; 351:2839-2849 ... Supercourse: Epidemiology the Internet and Global Health This course is designed to provide an overview on epidemiology and the Internet for medical and health related students around the world based on the concept of ...
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