Download BookProtein Metabolism and Homeostasis in Aging (Advances in Experimental Medicine and Biology)

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Aging is loosely defined as the accumulation of changes in an organism over time. At the cellular level such changes are distinct and multidimensional: DNA replication ceases, cells stop dividing, they become senescent and eventually die. DNA metabolism and chromosomal maintenance, together with protein metabolism are critical in the aging process. The focus of this book is on the role of protein metabolism and homeostasis in aging. An overview is provided of the current knowledge in the area, including protein synthesis, accuracy and repair, post-translational modifications, degradation and turnover, and how they define and influence aging. The chapters mainly focus on well-characterised factors and pathways, but new areas are also presented, where associations with aging are just being elucidated by current experimental data. Protein turnover, the balance between protein synthesis and protein degradation are carefully maintained in healthy cells. Chapters 1 and 2 illustrate that aging cells are characterised by alterations in the rate, level and accuracy of protein synthesis compared to young ones, and that mRNA translation, essential for cell growth and survival, is controlled at multiple levels. The theory that growth and somatic maintenance are believed to be antagonistic processes is described in Chapter 3: inhibition of protein synthesis results in decreased rates of growth and development, but also confers an extension of lifespan, as shown for example by the effects of dietary restriction in various models organisms. Biology - Wikipedia Biology is a natural science concerned with the study of life and living organisms including their structure function growth evolution distribution ... Rosuvastatin to Prevent Vascular Events in Men and Women ... Original Article. Rosuvastatin to Prevent Vascular Events in Men and Women with Elevated C-Reactive Protein. Paul M Ridker M.D. Eleanor Danielson M.I.A. Francisco ... Professor Luonan Chen - sysbio.ac.cn Professor Excutive director Key Laboratory of Systems Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences ; Present address (office ... Stress and Cell Death in Yeast Induced by Acetic Acid ... Stress and Cell Death in Yeast Induced by Acetic Acid InTechOpen Published on: 2012-01-25. Authors: M. J. Sousa P. Ludovico F. Rodrigues et Meta-Analysis of the Effects of Soy Protein Intake on ... Ingestion of vegetable protein in place of animal protein appears to be associated with a lower risk of coronary heart disease 12; this effect may reflect decreases ... Hypophosphatemia - Diseases & Conditions - Medscape Reference Hypophosphatemia is defined as a phosphate level of less than 2.5 mg/dL (0. ... Phosphate is a predominantly intracellular anion with a concentration of ... CCL2 - Wikipedia The chemokine (C-C motif) ligand 2 (CCL2) is also referred to as monocyte chemoattractant protein 1 (MCP1) and small inducible cytokine A2. CCL2 is a small cytokine ... Science Conferences Biology Symposium Scientific ... FASEB organizes over 30 Science Research Conferences around the globe each year covering popular biology medical and experimental research breakthroughs and ...
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